In vitro effect of calcium hydroxide combined
with chlorhexidine or stannous fluoride in
reducing Candida albicans in human root
canal
Authors :
- Siripen Wanasaengsakul D.D.S., Ph.D.
- Chalermkwan Puworawan D.D.S., M.Sc.
- Tipapun Setsirisombat D.D.S.
- Karnnapat Peetiakarawach D.D.S.
Abstract :
Objective To evaluate the effectiveness of calcium hydroxide combined with chlorhexidine or
stannous fluoride in disinfecting the Candida albicans infected human root canal in vitro.
Material and Methods Antifungal effect of reagents was examined by using agar-diffusion test and
counting colony forming unit of C. albicans existed in the root canal after 7 days intracanal medication.
Acid-base changing of chemical agents was also examined.
Results Three types of calcium hydroxide pastes could inhibit the growth of Candida on Sabouraud
dextrose agar, although the statistical differences among them were not found. The pH of calcium
hydroxide pastes were all more than 12. Calcium hydroxide combined with chlorhexidine or stannous
fluoride could significantly reduce colony forming unit in Candida infected human root canal, whereas
conventional calcium hydroxide were unable to do so.
Conclusion Calcium hydroxide combined with chlorhexidine or stannous fluoride could reduce the
colony forming unit of C. albicans within human root canal.
(CU Dent J. 2008;31:371-84)
Keywords :
calcium hydroxide; Candida albicans; chlorhexidine; root canal treatment; stannous fluoride
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