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Role of PPAR-γ in regulating
osteoclastogenesis
Authors :
- Wantida Sriarj D.D.S. (Hons), Higher. Grad. Dip. (Pediatric Dentistry), Ph.D.
Abstract :
Osteoclasts are cells that play a crucial role in bone remodeling. These cells are derived from monocyte-macrophage lineage of hematopoietic stem cells in bone marrow. RANK-RANKL interaction has been demonstrated to be a key mechanism of osteoclastogenesis, however, recent reports revealed the novel role of peroxisome proliferator-activated receptor gamma (PPAR-γ) in the regulation of osteoclast formation. In this review, the novel function of PPAR-γ in osteoclastogenesis will be discussed. Generally, PPAR-γ has been known to play a role in metabolism of glucose and lipid, including promotes adipocyte differentiation and inhibits osteoblast differentiation. Evidence suggested that PPAR-γ could also work in accordance with RANK-RANKL system in regulating osteoclastogenesis. The novel function of PPAR-γ will not only expands our knowledge in the mechanism of osteoclastogenesis but also suggests the correlation between glucose metabolism and osteoclast formation.
(CU Dent J. 2013;36:207-20)
Keywords :
osteoclast; osteoclastogenesis; PPAR-γ
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