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Acemannan in orabase did not cause
allergy to skin and oral mucosa in a
short-term exposure
Authors :
- Suwimon Jettanacheawchankit, D.D.S., Ph.D.
- Polakit Sangvanich, B.Sc, M.S., Ph.D.
- Pasutha Thunayakitpisal, D.D.S., Ph.D.
Abstract :
Objective To evaluate the allergic reaction of skin and oral mucosa to acemannan orabase in a shortterm
observation.
Materials and methods Forty-eight healthy subjects (24 females and 24 males) participated in this
study. The closed patch test was used to observe and compare the skin reaction after exposure to 0.5%
acemannan orabase and plain orabase (gelatin, pectin, carboxymethylcelluose sodium, liquid paraffin,
and polyethylene glycol) for 48 and 72 hours. For the oral mucosal reaction, the repeated oral
application test was performed. The participants were instructed to apply the 0.5% acemannan orabase
onto their lower labial mucosa 3 times per day after meals for 7 consecutive days. The area was
interpreted according to the International Contact Dermatitis Research Group. The data were collected
and the tissue reaction was described.
Results Neither dermal reaction nor oral mucosal reaction to acemannan orabase were detected after
3 and 7 days of application, respectively.
Conclusion Acemannan orabase did not cause allergy to the skin and oral mucosa in a short term
observation.
(CU Dent J. 2016;39:1-8)
Keywords :
Acemannan; AceAloe vera; orabase; patch test; repeated oral application test.
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